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Some of the newest therapeutics involve genetically modified cells. Tisagenlecle...

Jan 30, 2024

Some of the newest therapeutics involve genetically modified cells. Tisagenlecleucel is a genetically modified cell immunotherapy used to treat B-cell acute lymphoblastic leukemia. This immunocellular therapy involves collecting

T

cells from a patient. These T cells are then genetically engineered to express a protein that allows them to target and kill leukemia cells with a specific antigen on the cell surface. These modified

T

cells are introduced back into the patient's body. Which of the following are likely to be true for the therapeutic tisagenlecleucel based on what you know? (Select all that apply.) The treatment can only be delivered by infusion or injection. This treatment is convenient for the patient. This treatment is invasive for the patient. This treatment is a small molecule drug.

Key Concept

Delivery Method of Tisagenlecleucel

Explanation

Tisagenlecleucel is delivered via infusion or injection because it consists of living cells that must be administered directly into the bloodstream.

Key Concept

Invasiveness of Tisagenlecleucel Therapy

Explanation

The process of collecting T cells, genetically modifying them, and reinfusing them into the patient is invasive, involving multiple medical procedures.